HPMC K100

Bilayer floating tablets of Drotaverine HCL were developed by direct compression method. Immediate release layer contains 20 mg of drug and super disintegrant sodium starch glycolate, serves the purpose of loading dose. Sustained release layer contained HPMC K100, natural polymers like xanthan gum, guar gum, karaya gum release the drug for 12 hours’ time. Sodium bicarbonate and citric acid are used to produce effervescence. Floating lag time of optimized tablet is 92 sec, whereas floating duration is more than 12 hours. FTIR results revealed that there was no interaction between drug and HPMC K100 / xanthan gum. The post compression parameters of developed tablets were found to be satisfactory. In this study, it was confirmed that the formulations containing HPMC K100, have shown better floating properties and finally the formulation containing a combination of HPMC K100 and xanthan gum in 3:1 ratio, has exhibited decent sustained drug release properties. The release kinetics of optimized formulation prepared with the combination of HPMC K100 and xanthan gum followed zero order kinetics.

Lisinopril dihydrate (LSP) primarily used in the treatment of hypertension, congestive heart failure and heart attack. Floating matrix tablets of LSP prepared with a view of prolonging gastric residence time with a controlled release mechanism to achieve improved patient compliance, least side effects, better drug therapy and all aspects of an ideal drug delivery system. Floating matrix tablets were prepared by  wet granulation technique using  varying concentrations of different grades of gel forming polymers like HPMC K100, HPMC K15, HPMC K4M with sodium bicarbonate as gas generating agent and evaluated for the physico-chemical parameters, floating lag time, total floating time, in vitro dissolution study and swelling studies. The physico-chemical properties of all the formulations were found to be within the prescribed official limits. FTIR study reveals that there was no interaction between drug and excipients. The amount of drug released from various FDDS formulations was found to be in the order of HPMC K100M > HPMC K15M > HPMC K4M. From among all the formulations, the formulation LF-9 with 30% HPMC K15M showed the best result in terms of the required lag time (82±5 sec) and floating duration of 12 h and releasing 99.5% of the drug in 12 h and is considered as the ideal formulation. The dosage form can control the release, avoid dose dumping and extend the duration of action of a drug with prolonged floating time.

Development of pH sensitive zolmitriptanin-situnasal gel was aimed to improve absorption and patient compliance. In the present research work, mixture of Carbopol 940 and Hydroxypropylmethylcellulose K100 were used to confer pH sensitive gelation property. Different formulation was prepared by varying the concentrations of Carbopol 940 and HPMC K100.These formulations were evaluated for parameters like pH, drug content, viscosity, mucoadhesive strength, gel strength, in-vitro drug release, in-vitro permeation and drug excipients compatibility. In this formulation the release profile depend on the concentration of Carbopol 940 and HPMC K100. A 32 factorial design was applied to see the effect of variables Carbopol 940 (X1) and HPMC K100 (X2) on the various models to ascertain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The results of the F-statistics were used to select the most appropriate model. Formulation containing Carbopol 940 (0.1%) and HPMC K100 (0.2%) was found to be optimum. The study indicate that the formulation was effective in providing in-vitro release of drug and the mucoadhesive formulation.