Extrusion and speronization

Tolterodine is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Tolterodine tartrate having side effects mainly  dry mouth and other side effects like constipation ,headache ,stomach pain hence controlled release formulation  is prefer for tolterodine tartrate and this controlled release formulation is also reduced the frequency of dosing. In market control release capsules dosage form is available, we have planned, new controlled release tablet dosage form which is prepared by using multi unit particulate drug delivery system. Tolterodine Tartrate controlled release MUPS tablets were formulated by using insoluble inert starting seed or core which was prepared by using extrusion spheronization technique. use of water soluble material combined with tolterodine create greater amount of osmotic pressure causing the controlled release pellets burst and dump the drug. Hence water insoluble core pellets were used in this formulation the controlled release formulation comprised of a) water insoluble insert core b) Drug loading layer comprising of tolterodine c) Controlled release coating surrounding drug layer d) pellets mixed with conventional tablet excipients compressed into tablets. The aim of this study focused on the introduction of new alternative core for formulation of control release MUPS tablets and also studied the effect of protective plasticizer coating layer on extended release pellets prior to compression into MUPS tablets.