Ethanol induced ulcer model

In the present study Anti ulcer activity of Ethanolic Extract of flower of Nymphaea alba Linn were investigated. The Anti ulcer activity of Ethanolic Extract of flower of Nymphaea alba were evaluated by Pylorus ligation & Ethanol induced ulcer model in experimental rats. In both models the common parameter determined was ulcer index. The Ethanolic Extract of Nymphaea alba (200 & 400 mg/kg) treat the Ulcer and produced significant inhibition of the gastric lesions induced by Pylorus ligation induced ulcer & Ethanol induced gastric ulcer. Preliminary Phytochemical analysis of Ethanolic Extract of Nymphaea alba revealed that the presence of various phytoconstituents Alkaloids, Carbohydrates (Polysaccharides), Glycosides, Steroids, Flavonoids and Tannin & Phenolic compound. The extract (200 mg/kg & 400 mg/kg) showed significant reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that Nymphaea alba Linn flower extract have potential Anti ulcer activity in the both models. These results may further suggest that Ethanolic extract was found to possess Antiulcerogenic as well as ulcer healing properties, which might be due to its Anti-secretary activity.

The anti-ulcer activity of leaves of benzene and pet ether extract of cleome gynandra inn was investigated in  ethanol induced ulcer model in the male wistar albino rats. The parameters evaluated are ulcer index ,volume of gastric juice, gastric acidity, ph of gastric juice. Pet ether and benzene extract  at doses of 150 mg/kg produced significant inhibition of gastric lesion induced by ethanol induced gastric ulcer. The extract shows significant reduction in gastric volume ,and ulcer index when compared to control. The present study indicates that leaves of benzene and pet ether extract of cleome gynandra inn have potential anti ulcer activity in ethanol induced ulcer model. Further the study also implies that dietary polyphenolic phytochemical especially the flavonoid, saponins accumulated in leaves may supply substantial anti-ulcer agents, which in turn may inhibit the development of several chronic  diseases and there by provide health promoting effect.