Domperidone. Sustained release. Hydroxyl propyl methyl cellulose. Direct compression. Floating lag time.

  The present work investigates the formulation and optimization of floating tablets of Domperidone. Formulations were optimized for gas generating agent content, different viscosity grades of HPMC and its concentration. Study revealed that percentage of NaHCO3 and different grades of HPMC had a major influence on release of drug from hydrophilic matrix tablets and floating properties. Eleven trial batches were undertaken in order to optimize and find out the most suitable formulation and evaluated for various parameters like weight variation, hardness, thickness, friability, floating lag time, total floating time, swelling index, dissolution profile and stability study. The formulation F11 containing 20 mg/ tab. HPMC (K100M) was optimized as the best formulation. Optimized formulations were studied for effect of hardness on floating properties and as well as accelerated short term stability study. Hardness of tablets had greater impact on floating lag time which might be due to decreased porosity. Dissolution profiles were subjected to various kinetic drug release equations and found that drug release from hydrophilic matrixes occurred via anomalous transport mechanism (i.e.) follows both diffusion and erosion mechanism. Hence it is evident from this investigation that gas powered matrix tablet could be promising delivery system for Domperidone with sustained release action and improved drug availability. Keywords: Domperidone. Sustained release. Hydroxyl propyl methyl cellulose. Direct compression. Floating lag time.