Differential Scanning Calorimetry

The proton pump inhibitor are rapidly degraded in the acidic medium Thus it has less bioavailability since it is acid labile , mostly available in  the enteric coated tablet to prevent acids degradation .But the onset of action is delayed. It is a great challenge to formulate simple compression solid dosage form of these drugs with considerable stability and efficacy. The Cocrystals of Lansoprazole was prepared by solvent evaporation using nicotinamide as a coformer. The prepared cocrystals were characterized by FTIR, SEM, DSC and XRD study. The cocrystals also evaluated for solubility and acid stability studies. The formation of Lansoprazole cocrystals were confirmed using FTIR, DSC showed the decreased in the melting point of cocrystals corresponds to melting point of pure Lansoprazole. The SEM also confirmed the changes in the habit of crystals. The acid stability study performed using HPLC and confirmed that the Cocrystals of Lansoprazole stable upto 75 % than the pure lansoprazole in 0.1 N HCL.

The primary objective of sustained release drug delivery system is to ensure safety and to improve efficacy of drugs as well as patient compliance. Using controlled drug delivery system the drug release pattern can be controlled within narrow therapeutic range, which leads to minimize the side effect and ensure the safety. The aim of the study is to design, characterize and evaluate ciprofloxacin hydrochloride sustained release tablets using various viscosity grades of HPMC. As ciprofloxacin HCl has very short half life (nearly 3½ to 4 hr) hence multidose therapy for conventional tablets, (250 mg, 500 mg twice a day) is necessary to get the desired therapeutic level. Hence in the presence study attempt has been made to formulate the sustained release tablets of ciprofloxacin HCl using different viscosity grades of HPMC i.e. HPMC K4m,  HPMCK15M, HPMC K100M with different drug polymer ratio to reduce the dosing frequency, minimize the flections of plasma drug concentration, evaluation has been done of the prepared formulation and compared with the standard. The prepared granules were free flowing and characterized for drug content, DSC, X-ray diffraction study and FTIR. The X-ray diffraction study & DSC obtained from various formulations showed no interaction within these formulations. The in-vitro release studies were performed using pH 7.4 phosphate buffer for 12 hours from which the different drug polymer ratios are followed zero order kinetics.