DMBA

Cancer is the second leading cause of death globally. Cassia fistula (CF), a member of Leguminosae family, is Native to India, Amazon and Sri Lanka, is widely used for its medicinal properties in Indian system of medicine for various ailment from the ancient time. The present investigation was undertaken to investigate the anticarcinogenic action of Cassia fistula L.  extract on 2-stage skin carcinogenesis model in Swiss albino mice. The papilloma were produced on mice skin by DMBA and promoted by croton oil and one weeks later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks). After 16 weeks at the time of termination of the experiment estimation of GSH from the liver and blood tissue of the animals were also done by the method of Beutler et. al. (1963). the outcomes of the papilloma study and GSH estimation was correlated and it was found to be preventive for the formation as well as persistence of papilloma. 21 no. of papilloma were found in CF treated mice as compared to (35) untreated control mice. Our results suggest that Cassia fistula can be a cost effective future herbal alternative medicine for cancer treatment.  

The purpose of this study is to investigate the glycoprotein and efficacy of combination of paclitaxel along with Di allyl sulfide against skin cancer in experimental animals. Skin cancer is the most common form of human cancer. It is estimated that over 1 million new cases occur annually. The annual rates of all forms of skin cancer are increasing each year, representing a growing public concern. The most common warning sign of skin cancer is a change in the appearance of the skin, such as a new growth or a sore that will not heal. Skin cancer is caused by chemical carcinogens and Papilloma virus infection. Skin cancer was induced in rats by 7, 12 Di methyl benz(a) anthracene (DMBA) at the dosage of 5 µg was dissolved in 100µl and administered into experimental animals for 28 weeks. In this study, we demonstrated that combination of paclitaxel and Di allyl sulfide protects the rats from a lethal dose of DMBA for 30 days. The levels of glycoprotein in plasma, skin and liver were found to be increased in the cancer bearing animals when compared with control animals. Treatment of Paclitaxel along with Di allyl sulfide to cancer induced animals showed significantly decreased levels of glycoprotein levels when compared with cancer induced animals. The treatment with combination of paclitaxel and Di allyl sulfide effectively reduced glycoprotein levels. So, from the obtained results it is concluded that paclitaxel and Di allyl sulfide is capable of restoring the skin architecture. Key words: Paclitaxel, Di allyl sulfide, DMBA, Skin cancer.