Coumarin

A series of 1-(substituted -2-oxoquinolin-1(2H)-yl) urea and thiourea have been synthesized by using coumarin derivatives and semicarbazide in presence of ethanol as a solvent. Coumarin derivatives were prepared via pechmann condensation by adding a mixture of substituted phenol and ethyl acetoacetate in concentrated sulfuric acid. Coumarin derivatives then subjected to condensation with semicarbazide and thiosemicarbazide. The structure of all these synthesized compounds has been established on the basis of chemical transformation, IR and 1HNMR spectral studies. Synthesized compounds are showing amazing antibacterial activity for common food borne pathogens such as Escherichia coli, Shigella flexneri, Staphylococcus aureus, and Bacillus cereus.

Synthesis of coumarin based random copolyester was prepared by the reaction of biscoumarin monomer 1 and anthroquinone3 with azeloyl chloride through interfacial polycondensation technique by using phase transfer catalyst. The chemical structure of the copolyester was investigated by Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. Disc diffusion method was employed to investigate the antifungal activity of the synthesized copolyester.