Biological activities

Pyrazolines, the eminent five-membered nitrogen-containing heterocyclic compounds, have received significant interest in the fields of therapeutic and agricultural chemistry because of their broad spectrum of biological activities. The Pyrazoline ring is relatively stable and has inspired chemists to carry out various research activities. Pyrazolines, a class of electron-rich nitrogen heterocyclic compounds, possess a broad range of pharmacological functions such as anticancer, antitubercular, antimalarial, antibacterial, antifungal, anti-inflammatory, analgesic, anticonvulsant, and antioxidant activities. This review provides an outline on the recent grade of pyrazoline derivatives in terms of synthesis and various applications to realize their full potential as drugs.

In order to explore pharmaceutical activity of marine fungi fungal samples were collected from both marine water and marine mud  of coastal lines in Andhra Pradesh, India. . Fungal samples were screened and identified as C.geniculatus. Screened marine fungi were evaluated for therapeutic activities which include antimicrobial, Anti-oxidant, Antidiabetic and anti-inflammatory activities. Pure cultures of these strain were fermented for 10 to 15 days, which resulted in the production of crude extract. The crude extract was separated, condensed,, weighed and stored for further analysis. Crude extract was analyzed for antibacterial and antifungal activities using agar well diffusion method at four different concentrations. Anti-oxidant by DPPH method, Antidiabetic by alpha amylase activity and anti-inflammatory activities by 5-LOX methods were done.  Antimicrobial activity was done with nine bacterial strains and five fungal strains. C.geniculatus showed good inhibitory activity against bacterial Streptococcus mutans, Lactobacillus casei and Enterococcus faecalis strains and  fungal strain Fusarium oxysporium. At maximum concentration DPPH method showed 92.58% radical scavenging activity, amylase activity showed 79.26% activity and 5 LOX method showed moderate activity at 51.72% of anti-inflammatory activity at this concentration.

Thiophene a five member heterocycles had been found with enormous biological activities with the suitable modifications in the structure. The present review is an attempt made to direct the attention of the researchers towards the thiopene ring for the development of newer chemical entities which are quite useful in the treatment of various life threatening diseases and disorders This review article covers the most active thiopene derivatives that have shown considerable biological actions such as antimicrobial, anti-inflammatory. This review also discusses the structure-activity relationship of the most potent compounds. It can act as an important tool for medicinal chemists to develop newer compounds possessing thiopene moiety that could be better agents in terms of efficacy and safety