Antidiabetic activity

The most popular solid dosage forms are being tablets and capsules; one important drawback of these dosage form for some patients, is the difficulty to swallow. Drinking water plays an important role in swallowing of oral dosage forms. For these reasons tablets that can rapidly dissolve or disintegrate in the oral cavity have attracted a great deal of attention. Mouth dissolving tablets are not only indicated for people who have swallowing difficulties, but also are ideal for active people. The concept of formulating Mouth dissolving tablets containing Metformin Hydrochloride offer a suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability.

Several five membered aromatic systems having three heteroatoms at symmetrical positions such as thiadiazoles have been studied extensively owing to their interesting pharmacological activities.  Compounds containing thiadiazole moiety possess interesting biological activity due to strong aromaticity of this ring system that leads to great in vivo stability and lack toxicity. Thiadiazoles are an important class of heterocyclic compounds that exhibit diverse applications in organic synthesis, pharmaceutical and biological applications that exhibits a wide variety of biological activities like antimicrobial, anti-inflammatory activity, antitubercular activity, antidiabetic activity, diuretics, antidepressant & cytotoxic activity. Modification of the thiadiazole ring has proven highly effective with improved potency and lesser toxicity. The present review highlights the recently synthesized thiadiazole possessing important biological activities.