Anti-inflammatory activity.

The aim of this work is to improve the anti-inflammatory activity of Lornoxicam through incorporating it in a topical gel using different polymers as Carbopol 934, Sodium carboxy methylcellulose or Sodium alginate. Various penetration enhancers (Glycerin, Polyethylene glycol or Sorbitol) were used with objective of enhancement in the percutaneous permeation of the drug. Formulations were evaluated for pH, drug content, rheological properties, spreadability, in-vitro drug release in phosphate buffer (pH 6.5) and permeation study through cellulose membrane. Anti-inflammatory activity of Lornoxicam gel was studied in rats by carrageenan induced paw edema method and compared with the commercial formulation (Feldene® gel). Considering physical properties, in-vitro release and in-vitro permeation studies, FS1 (Lornoxicam gel containing 1% Carbopol with 10% Sorbitol as penetration enhancer) was the best formula among the studied formulations, this formula also exhibited significantly higher anti-inflammatory activity in rats compared to Feldene® gel.

The aim of the study was to prepare and evaluate topical gels incorporating liposomes of Dexamethasone base. Multilamellar vesicular (MLVs) liposomes were prepared using thin film hydration method. By subjecting MLVs to sonication using Ultra homogenizer, SUVs were formed. Liposomes were composed of soya lecithin, cholesterol, and dexamethasone. Using these method different concentrations of dexamethasone liposomes were prepared and were successfully incorporated in 1% carbopol gels. Liposomes were characterized for their particle size using zeta sizer and entrapment efficiency by dialysis method. SUVs were evaluated for in vitro release. Viscosity of gel formulations was measured using Brookfield viscometer, Drug lipid compatibility was performed using FTIR spectroscopy. Liposomal gels were evaluated for in vitro release studies, ex-vivo permeation studies and pharmacodynamic studies (Anti-inflammatory activity). Results showed more localized and sustained effect with Liposomal dexamethasone gels than dexamethasone gel formulation.