Aloe vera

Infectious diseases (ID) circulating in the home and community remain a significant concern. Two factors are largely responsible first is the constantly changing nature and range of pathogens to which we are exposed and, second is the demographic changes occurring in the community, which affect our resistance to infections. The impact of hand hygiene is important to reduce transmission of ID in the home and community. The antibacterial soap as they contain triclosan which have huge amount of disadvantage and also alcohol base sanitizer which causes irritation due to skin drying, so we can replace it with herbal antimicrobial ingredients. The gel base Polyherbal handwash which prepared by using herbs to avoid the side effects are Azadirachta indica, Citrus Limonis, Aloe vera. The antimicrobial activity of prepared gel base polyherbal handwash was checked by using cup plate method. The microorganism used in antimicrobial test is staphylococcus auries, Candida albicans & bacillus subtillis. The result showed that gel based polyherbal handwash give more inhibition than available commercial synthetic handwash.

There are folkloric claims that Aloe vera has many pharmacological properties which have not been conclusively investigated. The aim of the study is to investigate the protective/toxic effects of chronic administration of Aloe vera gel extract on the haemostasis, haematology and renal handling of electrolytes, urea and creatinine in Wistar rats. The experimental animals were grouped into four: group 1(control) received vehicle and the test groups (2,3,4) received different doses of the extract (200, 300, and 500mg bwt/day ) respectively for 21 days. The bleeding time significantly decreased as the concentration of the extract increased while the clotting time increased relative to the control (P0.05). From the results of this study, it can be concluded that the chronic administration of Aloe vera gel did not disrupt the renal function of the wistar rats. 

Aloe gel is commonly used in herbal medicines. Many of the Aloe products available commercially, do not demonstrate beneficial effects, indicating the poor quality of the Aloe gel. Therefore, an efficient, reliable and accurate method is needed to evaluate the quality of Aloe products. The present research work discussed the development of a colorimetric and HPTLC method for the determination of Glucomannan (a marker compound for Aloe gel) in Aloe gels and its preparations. Shimadzu 1700 UV-Visible spectrophotometer was used for the colorimetric estimation. In the colorimetric method developed obeyed the Beer’s law in the concentration range of 50-90 μg-ml-1 with r2 of 0.999. CAMAG HPTLC instrument was used. The mobile phase comprised of n-butanol : ethanol : water : acetic acid (2 : 4 : 4 : 0.05 v/v) was used for the development of chromatogram. The densitometric scanning was done by TLC scanner III (CAMAG) in absorbance mode at the wavelength of 488 nm. After spraying with anisaldehyde sulfuric acid the system was found to give compact spots for glucomannan (Rf value of 0.69±0.02). The data obtained showed good linearity (r2 = 0.995) with respect to peak area in the concentration range of 400-1400 ng spot-1.