Active Pharmaceutical Ingredient

Bilayer tablet is the novel technology for the development of controlled release formulation. Developing a combination of two or more active pharmaceutical ingredients in a single dosage form is known as a bilayer tablet. Bilayer tablet is more suitable for gradual release of two active ingredients in combination. The preparations of bilayer tablet were needs due to separate incompatible active pharmaceutical ingredient (APIs) for each other. Bilayer tablets material involves both the compressibility and consolidation. The primary objective of sustained release drug delivery is to ensure safety and to improve efficacy of drugs as well as patient compliance. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. In the case of bi-layered tablets drug release can be rendered almost unidirectional if the drug can be incorporated in the upper non-adhesive layer its delivery occurs into the whole oral cavity. Keywords: Active Pharmaceutical Ingredient, Bi-layer tablet