and Atul Srivastava

Even today the most preferred delivery of drugs is still through oral route but because of some inherited limitations with this route, various other routes have been explored including transdermal. Delivery and complete absorption of the drugs is the major concern these days due to various reasons including poor solubility and incomplete bioavailability, this could be due to incomplete presystemic absorption or presystemic degradation. Transdermal drug delivery system is the method by which the drug absorption occurs through the skin primarily for its systemic effect. It provides better therapeutic efficacy and safety for the administration of insulin. Most of the oral anti-diabetic drug exhibit low bioavailability and hence a poor patient compliance. Hence, it can be used as better site for delivery of numerous drugs including proteins and peptides such as insulin.

Solid lipid nanoparticles (SLNs) are the superseding drug delivery system in the nanotechnology sphere. SLNs has been developed at the beginning of 1990s with potential applications in the field of pharmaceuticals, cosmeceuticals, clinical medicine along with research as a substitute to the traditional colloidal carrier systems such as emulsions, liposomes since they exclude those downsides of the traditional system. SLN s offers a great way for controlled drug delivery and site targeting drug delivery as well. This article gives general information about the solid lipid nanoparticles, their production procedures and characterization. In addition to that, the recent advancements of drug delivery systems using SLNs were reviewed.