Venkata Rao Chunduri

The present study will focus mainly on the new series of 1,2,3- triazoles linked with 7-amino-4-methyl coumarin (4) are synthesized using Click reaction. All the newly synthesized compounds (7a-q) are characterized by analytical and spectroscopic methods (IR, HRMS, 1H and 13C-NMR) and subjected to cytotoxicity screening against a panel of six different human cancer cell lines viz. Hela, PANC1, HepG2, SKNSH, MDAMB and IMR 32 cell lines. Interestingly, among the tested molecules, some of the analogs displayed better cytotoxic activity. Out of the synthesized triazoles (7a-q), compounds 7h, 7i and 7l showed potent activity, as 7h and 7l showed more potent activity against IMR32 cell line with GI50 of 0.015 and 0.02 μM, respectively and 7i with GI50 of 0.02 μM against SKNSH cell line. Further photophysical properties (UV & fluorescence) for these compounds (7a-q) are also discussed.