Varsha M. Jadhav

The methanolic extract of Punica granatum (PUG), Glycyrrhiza glabra (GLA) and their combination (PUG-GLA) were evaluated for their wound healing activity using excision wound model in rats. Rats treated with PUG-GLA showed higher rate of wound contraction, significant decrease in epithelization period and significant increase in hydroxyproline content of granulation tissue when compared with the controls. The histological examination of treated wounds showed that the original tissue regeneration was much greater in PUG-GLA, with increase in the restoration of collagen fibers, fibroblasts, blood vessel formation and hair follicle regeneration.

  Targeted drug delivery to the colon is more desirable for local treatment of a variety of bowel diseases and systemic delivery of protein and peptide drugs. Targeting depends on exploiting a unique feature of specific site and protecting the drug until it reaches to the site. To achieve the delivery of intact drugs to the colon, different primary as well as potential novel approaches are used. To achieve the maximum site specific delivery of drugs to colon, combination of two or more approaches are preferred over individual approaches. Because of limited success of primary approaches newly developed approaches are preferred.