V.V. Rajesham

The excess use of drugs for various ailments is resulting in increasing cases of drug-induced nephrotoxicity. Acute kidney injury is the most common type of drug-induced nephrotoxicity, which accounts for 85% of cases of nephrotoxicity. Herbal medications, due to the presence of various phytoconstituents, possess nephroprotective activity and are used in the treatment of kidney disorders like acute kidney injury, nephrotic syndrome, chronic interstitial nephritis, etc. The present review aimed to elucidate the list of medicinal plants which are scientifically proven to have nephroprotective activity against drug-induced nephrotoxicity. 

To evaluate Nephrpotective potential of Polyherbal methanolic extraction (Terminalia chebula, tinospora cordifolia, Phyllanthus emblica, Portulaca oleracea) against gentamicin (GM) induced Nephrotoxicity and renal dysfunction. It was observed that the GM treatment induced significant elevation (P

Kidneys are complex organs, which perform several important functions. Though the formation of urine is their most obvious role, but they also perform the vital co-ordination of water and salt metabolism, acid-base balance and secretion of hormones. The effects of occupational or therapeutically exposure to toxic metals on kidney have been known for many years. A large number of chemicals in common usage are potential nephrotoxic viz. Glycols (plastics solvents), paints, lacquers, cosmetics and flavouring extracts. The nephropreotective activity of the poly herbal formulation (composed of the extracts from Terminalia chebula, tinospora cordifolia, Phyllanthus emblica, Portulaca oleracea) was evaluated in Gentamicin induced nephrotoxicity in rats, Gentamicin like other aminoglycoside antibiotics causes nephrotoxicity by inhibiting protein synthesis in renal cells. The serum creatinine and blood urea nitrogen (BUN) were found to be significantly increased in rats treated with only gentamicin, whereas treatment with PHME the effect of gentamicin indicating nephroprotective activity. Among various doses, 200mg/kg, 400mg/kg has shown good nephroprotective activity.