T.Mallamma

The purpose of this research was to develop mouth dissolve tablets ofdomperidone andpantoprazole, were prepared by direct compression technique. Pantoprazole inhabits gastric acid formation and thereby it is very efficient for the treatment of gastric and duodenum ulcers. Domperidone, an antiemetic drug, has been used as an add-on treatment in adults and children. The tablets were prepared using microcrystalline cellulose as diluent and  aspartames as sweetening agent along with three different levels of disintegrant. The superdisintegrant used in this study were CCS and SSG. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time (DT) and dissolution study. formulation prepared with 30% of CCS showed Disintegration time of 20seconds in vitro. Also the hardness, friability, dissolution rate of prepared tablets (batch F6) were found to be acceptable according to standard limits.

For the past few decades, there has been a considerable research interest in the area of drug delivery using particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules.  Nanoparticles promise to revolutionize medicine and increasingly used in drug delivery. The purpose of this review is to explore the design, development of nanotechnology, different method of preparation and application. By making the drug into nanoparticles by using different method of preparation, which may alleviate the manifestations of disease with minimal dose and less toxicity. These drug delivery systems can be potentially translated into targeted cellular and tissue-specific clinical applications designed to achieve maximal therapeutic efficacy with minimal side effects.