Swapnil P. Chaudhari

The aim of the present study was to prepare buccoadhesive sustained release tablets of sumatriptan succinate using various permeation enhancers to release the drug for extended period of time with reduction in dosing frequency. In the present work sumatriptan succinate was used as a model drug and interaction studies performed using FTIR spectroscopy and DSC revealed that there was no drug, polymer and permeation enhancer interaction. Fulvic acid was extracted from shilajit by using resins. Fulvic acid was characterized by various spectroscopic techniques. Buccoadhesive sustained release tablets of sumatriptan succinate with various permeation enhancers were prepared by direct compression method using bioadhesive polymers like Carbopol 934 and HPMC K100M. The physical characteristics like surface pH, swelling index, in vitro mucoadhesion time, in vitro mucoadhesion strength, in vitro drug release study and in vitro permeation study. The in vitro release study showed 99.88%, 99% and 99.40% of drug release with fulvic acid, chitosan and beta cyclodextrin respectively. The permeation study showed 90%, 82% and 78% of drug permeated with fulvic acid, chitosan and beta cyclodextrin respectively. Sumatriptan succinate release from the buccoadhesive system was extended and exhibited a non fickian drug release kinetics approaching to first order as the values of release rate exponent varied between 0. 97 to 0.99 resulting in a regulated and complete release until 8 hours.

In the present study, a series of novel quinazoline derivatives were synthesized by condensation with different aromatic amines via cyclized intermediate 2-phenyl-1, 3-benzoxazin-4-one.The chemical structures were confirmed by means of IR, H1 NMR. These compounds were screened for anti-bacterial (Staphylococcus aureus ATCC-9144, Escherichia coli ATCC-25922, activities by paper disc diffusion technique. The potency of antibiotic content in samples can be determined by chemical, physical or biological means. An assay was performed to determine the ability of an antibiotic to kill or inhibit the growth of living microorganism. The inhibition of microbial growth under standardized conditions may be utilized for demonstrating the therapeutic efficacy of drugs. Microorganisms employed in biological assay were of various types of bacteria for amino acid & antibiotics, fungi for vitamins & trace elements. The synthesized compounds were evaluated for anti-bacterial activity. Some of these synthesized compounds show significant anti-bacterial activity.