Sujata Mahapatra

The aim of this investigation was to develop and optimize Metformin Hydrochloride matrix tablets for sustained release application. The sustained release matrix tablet of Metformin Hydrochloride was prepared by wet granulation technique using Tamarind pulp polysaccharide. The polysaccharides obtained after extracted from natural source and evaluated for their colour, viscosity and pH. The prepared tablet was evaluated for their hardness, friability, drug content, In vitro dissolution, swelling studies. In vitro drug release profiles of Metformin Hydrochloride Tablet using Tamarind pulp polysaccharide formulation release of drug from the Tablet exhibited a sustained & controlled pattern over an extended time period. .The tablet formulation TF-1 was found to release the drug of about 95% after 12 hrs, The tablet formulation TF-5 was found to release the drug of about 70% after 12 hrs, thus concluded to have sustained drug release for longer period of time in sustained and controlled pattern when compared to other tablet formulations. Using Higuchi’s Model and the Korsmeyer equation, the drug release mechanism from the sustained release tablets was found to be Anomalous (non-Fickian) diffusion. Compatibility study confirmed that interactions do not exist between the drug and polymer.

The aim of this investigation was to develop and optimize Metformin HCl matrix tablets for sustained release application by response surface methodology based on two factor-three response factorial design. The effects of the amounts of polysaccharide from tamarind and polysaccharide from jackfruit in Metformin HCl matrix tablets on the properties of Metformin HCl sustained release matrix tablets drug release was analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized Metformin HCl matrix tablets showed prolonged sustained release of Metformin HCl over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism.

In the last few decades there has been an exponential growth in the field of herbal medicine. Herbal medicines have been the basis of treatment and cure for various diseases and physiological conditions in traditional methods of practice such as Ayurveda, Unani and Siddha. Medicinal components from plants play an important role in conventional as well as western medicine. They were the sole source of active principles capable of curing man’s ailments. Thus natural products have been a major source of drugs for centuries. Mimusops elengi, commonly called ‘Bakul’ is a medicinally important plant of family sapotaceae. All parts of the plant including stem, bark, leaves, fruit, root and seeds in all stages of their maturity have medicinal properties. Taking into consideration the medicinal importance of the plant, the present review has made to explore the phytochemical and pharmacological potential of Mimusops elengi.