Smita T

Ophthalmic drug delivery is one of the most interesting and challenging endeavours facing the pharmaceutical scientist. The anatomy, physiology and biochemistry of the eye render this organ highly impervious to foreign substances. Various ophthalmic vehicles, such as inserts, ointments, suspensions and aqueous gels, have been developed to lengthen the residence times of instilled dose and enhance ophthalmic bioavailability1. The objective of the present work was to develop an ion activated in situ gelling system of Levofloxacin, a fluoroquinolone derivative used in external infections of the eye. Gellan, alone, was investigated as vehicle for the formulation of eye drops of Levofloxacin (0.5%), which would undergo gelation when instilled into cul-de-sac of the eye and provide sustained release during treatment of ocular infections. The developed formulations were therapeutically efficacious and provide sustained release of the drug during over a 8-hrs period in vitro2.

A simple, precise and economical UV Spectrophotometric method has been developed for the estimation of Tolterodine tartarate in bulk and pharmaceutical dosage form. The method is based on measurement of absorption at maximum wavelength of 283.0 nm. Linearity for detector response was observed in the concentration range of 10-50 μg/ml. The accuracy of the method was assessed by recovery studies and was found to be 99.80%. The LOD and LOQ were found to be 0.1865 and 0.5621 respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision, specificity and robustness and ruggedness. The results were validated statistically as per ICH Q2 R1 guideline and were found to be satisfactory. The proposed method was successfully applied for the determination of Tolterodine tartarate in commercial pharmaceutical dosage form.