Shyamala

OTC medications are essential for increasing access to healthcare since they allow people to self-medicate for mild ailments. In this project, the marketing difficulties of over-the-counter herbal and allopathic medications are compared. Despite being largely regarded as safe, natural, and culturally acceptable, herbal over-the-counter medications (OTCs) confront several challenges, including slower onset of action, clinical validation, standardization, and regulatory compliance. The strong scientific backing, stringent regulation, and quick therapeutic results of allopathic over-the-counter medications, on the other hand, make them vulnerable to price pressure, restrictions on promotions, and growing customer demand for "natural" substitutes. The study draws attention to variations in pricing policies, promotional restrictions, consumer perception, and regulatory frameworks. Antihistamine, antipyretic, antitussive, and NSAID case comparisons show differences in adverse effects, adherence, and market share. For both herbal and allopathic over-the-counter marketers to be successful in the cutthroat healthcare industry, they must ultimately embrace flexible tactics, guarantee evidence-based claims, and cultivate consumer trust. For both industries to thrive sustainably, patient-centered strategies, innovation, and responsible promotion are crucial.

Paleolithic diet also known as stone-age diet, is based on those food items that were available during the Paleolithic period, which dated from 2.5 million years ago to 10,000 B.C. This diet includes food items such as meat, fish, fruits, vegetables along with a very small number of cereals, roots, eggs, nuts, and excludes items like dairy products, grains, sugar, legumes, processed or refined oils, salt, coffee or tea, and alcohol. On one hand, the Paleolithic diet is beneficial in the case of chronic conditions like type 2 DM, cardiovascular diseases, obesity, and other such conditions. On the other hand, adherence to the Paleolithic diet leads to a few adverse effects like calcium deficiency, iodine, vitamin D, and more due to exclusion criteria of some food. Furthermore, evidence of clinical trials on a large population are needed as several trials conducted on a small sample will only lead to poor results resulting in lack of evidence. On a separate note, alternative diets are also opted for compensate the lack of elements to avoid any further medical consequences. Upcoming studies should throw light on clinically analyzing the health quality of excluding certain food items in the context of Paleolithic nutrition.

The present study was an attempt to prepare and evaluate Zolmitriptan 9 different oral disintegrating tablets using superdisintegrants like SSG, Crospovidone and Croscarmellose sodium. Formulations were evaluated for their micromeretic properties and post compression studies and found to be within the limits. Based on the disintegrating time and dissolution studies F9 was found to be best formulation. It was found that the sodium starch glycolate is much more effective than the other super disintegrating agents in the preparation of Zolmitriptan oral disintegrating tablets. DSC and FTIR data revealed that no interactions takes place between the drug and polymers used in the optimized formulation.

Rapid and accurate High performance liquid chromatography method is described for Simultaneous estimation of Perindropil and Indapamide from the combination tablet dosage form. The separation of two drugs was achieved on Phenomenax (C18) (4.6mm x 100mm, 3.5 mm) column. The mobile phase consists of Acetonitrile : Buffer Orthophosphoric acid 0.1% in the ratio of 40:60. The detection was carried out at a wavelength 230 nm. The method was validated for system suitability, linearity, accuracy, precision, robustness and stability of sample solution. The linear ranges for Perindropil and Indapamide were 8-40 μg/mL, 2.5- 12.5 μg/mL respectively with good recoveries i.e. 100.5% to 100.3%.

  Advancement in science and technology has leds to an evolution of controlled drug delivery as one of the important facets of novel drug delivery with an aim of designing therapeutically efficient dosage forms.  With this insight an attempt was made in designing an oral patch system developed with an inspiration to mimic transdermal drug delivery system. The hypothesis involved development of a compressed patch system for achieving steady therapeutic levels of a model antiprotozoal antibiotic Metronidazole. The patch system comprises of a poorly permeable layer, a mucoadhesive layer containing drug-loaded microspheres and a backing layer. The drug content of microspheres was found to be 50% with an average particle size of 100m. Individual layers of patch system were evaluated for folding endurance, flexibility, thickness and mucoadhesion test. Finally compressed patch system was folded and encapsulated into hard gelatin capsule, then subjected for in-vitro dissolution test in phosphate buffer and also for in-vitro diffusion across cellophane membrane and rat intestine. Drug-excipient compatibility studies revealed no interaction. The stability data further assured the stability of formulations. Thus formulations seem to match mostly gastro retentive category of sustained release forms through bio-adhesion approach concluding an easier, controlled and safer means of oral administration. Key words: Mucoadhesion, compressed patch system, gastro retentive device.

Rapid and accurate High performance liquid chromatography method is described for Simultaneous estimation of Metformin Hydrochloride and Sitagliptin Phosphate from the combination tablet dosage form. The separation of two drugs was achieved on HYPERSIL (250 x 4mm i.d) 5μ column. The mobile phase consists of Acetonitrile and phosphate buffer in the ratio of 45:55. The detection was carried out at a wavelength 260nm. The method was validated for system suitability, linearity, accuracy, precision, robustness and stability of sample solution. The linear ranges for Metformin Hydrochloride and Sitagliptin Phosphate were 20-120μg/mL, 2-12μg/mL respectively with good recoveries i.e. 99.16% to 99.89%.