Shaheda Sultana

The objective of the present investigation was to prepare colon targeted piroxicam loaded Eudragit S 100 microspheres and evaluate its properties. The microspheres were prepared by using "O/O solvent evaporation" technique. The formulation was optimized by investigating the influence of various process variables like stirring speed, drug: polymer ratio and percentage of emulsifier on the fabrication and the prepared microspheres were evaluated for in vitro properties. Piroxicam loaded Eudragit S 100 microspheres were successfully prepared using "O/O solvent evaporation" method. Microspheres prepared using 1:5 drug: polymer ratio, with a stirring speed of 1000 rpm, and 1.0% w/v concentration of emulsifying agent was selected as an optimized formulation. In vitro drug release were performed in pH 1.2 (0.1N HCl) for 2h and in pH 6.8 phosphate buffer for next 2h followed by 7 pH phosphate buffer up to 24 h. The release pattern of drug was slow at low pH values and increased on rise in pH. The drug release followed Higuchi model.

The present work aimed at preparing fast dissolving buccal films of Isradipine solid dispersion, since Isradipine is a poorly soluble drug and the rate of absorption is often controlled by the rate of dissolution. The purpose of developing a dosage form for a very quick onset of action and for improved bioavailability along with the convenience of administration i.e. without the problem of swallowing and using water. The rate of dissolution can be increased by incorporating the drug in a fast dissolving buccal film as a solid dispersion that prepared using polyethylene glycol (PEG4000) or polyvinyl pyrrolidone (PVP k30). The fast dissolving films of Isradipine solid dispersion were prepared by solvent casting method using Lycoat RS720 polymer and glycerin as a plasticizer. The formulated films were evaluated for their physiochemical parameters like disintegration time, surface pH, thickness & weight of the films, percent moisture absorption, folding endurance, drug content and stability testing. Different factors affecting the dissolution rate of solid dispersion and fast dissolving film were studied. It was seen that as the ratio of drug to PEG4000 or PVP k30 in solid dispersion increased the release rate increased and the solvent evaporation method gave greater drug release than fusion method. In fast dissolving film it was seen that as the concentration of Lycoat RS720 increased the release rate decreased and as the concentration of glycerin increased the release rate increased. Formulation F6 showed 98.89% drug release from the film within 7 minutes which is an essential character for faster absorption.