Shabaraya AR

In the present investigation an attempt has been made to prepare and evaluate medicated lollipop of mebendazole. One of the major health problems faced by hundreds of millions of school-age children is infection by helminths, more commonly known as worms. Mebendazole is used as a broad-spectrum anthelmintic. The conventional dosage forms like tablets, capsules, syrups etc are inconvenient for paediatric patients because of difficult to swallow tablets and capsules or unpleasant taste of drug. As a result, the demand for developing new technologies has been increasing day by day. Lollipops or lozenges are flavored medicated dosage forms intended to be sucked and held in the mouth or pharynx containing one or more medicaments usually in the sweetened base. Medicated lollipop is designed to improve patient compliance, acceptability and increase oral retention time. The lollipops were prepared by heating and congealing method using methylcellulose as polymer. Drug-excipient compatibility study was carried out using FT-IR. All the formulations were subjected to various physicochemical evaluations like weight variation, hardness, drug content, friability etc. The in-vitro dissolution study of F0 was found to be 96.14% at 15min whereas F1 was found to be 99.33% at 25min. Stability study was carried out as per ICH-Guidelines (Q1A) at 30oC and 65% RH. From the present study it can be concluded that addition of hydrophilic polymers yield good result to prolong oral retention time of lollipop. Medicated lollipop can provide an attractive alternative formulation in the treatment of paediatric patients.

The Microsponge Delivery System (MDS) is a unique technology used for controlled release and prolonged topical administration. Due to the difficulty that arouse in the release of the active ingredient over an extended period of time the fundamental need for the Microsponge technology arouse. The MDS consists of macroporous beads typically 10 – 25 microns in diameter loaded with the active pharmaceutical ingredient. When applied to the skin the MDS releases its active ingredient on a time mode and also in response to different stimuli like rubbing, temperature, pH etc. This technology is currently being used in sunscreens, skin care, cosmetics and prescription products.  It offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance and enhanced formulation flexibility. Innumerable studies have confirmed that microsponge systems are non irritating, non mutagenic, non allergic and non toxic. Microsponges are used mostly for topical drug delivery and have been recently used for oral administration and tissue engineering.