Microsponges: A Novel Drug Delivery System

The Microsponge Delivery System (MDS) is a unique technology used for controlled release and prolonged topical administration. Due to the difficulty that arouse in the release of the active ingredient over an extended period of time the fundamental need for the Microsponge technology arouse. The MDS consists of macroporous beads typically 10 – 25 microns in diameter loaded with the active pharmaceutical ingredient. When applied to the skin the MDS releases its active ingredient on a time mode and also in response to different stimuli like rubbing, temperature, pH etc. This technology is currently being used in sunscreens, skin care, cosmetics and prescription products.  It offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance and enhanced formulation flexibility. Innumerable studies have confirmed that microsponge systems are non irritating, non mutagenic, non allergic and non toxic. Microsponges are used mostly for topical drug delivery and have been recently used for oral administration and tissue engineering.