Sagar A. Jadhav

The novel series of 2-mercaptobenzimodazole derivative were synthesized by using secondary amine i.e. diethyl amine and aromatic aldehyde. In Mannish reaction instead of formaldehyde other aromatic aldehyde was used. This was main aim of present study. Same derivatives were synthesized by using Microwave technique & reaction time, practice yield were compared. The purity of synthesized compounds was checked by Melting point and TLC and their structure was established by various analytical techniques such as IR,1HNMR, Mass spectral studies. These Compounds were screened for their  Anticonvulsant activity.  Anticonvulsant activity was evaluated by PTZ induced model. Keyword- Mannich reaction, 2-Mercapto Benzimidazole, Aromatic aldehyde.

Plants have been used as medicines for thousands of years. They have always been used as a rich source of biologically active drugs. According to WHO (World Health Organization) report, about 80% of the population, mostly in developing countries still depends on traditional medicinal system for their primary health care. The present investigation is focused on the phytochemical investigation of abutilon indicum species for anticancer activity. The Abutilon L. genus of the Malvaceae family comprises about 150 annual or perennial herbs, shrubs or even small trees widely distributed in the tropical and subtropical countries. The aqueous extract of the A. indicum L. showed significant cytotoxic activity against both the selected cancer cell lines viz. human breast cancer cell line MCF 7 and human lung cancer cell line A 549.