S.M. Ashraful Islam

Practically water insoluble Simvastatin has been accused for being poorly absorbed from gastro intestinal tract. With an aim to improve the solubility and dissolution characteristics of the drug, solid dispersion and surface solid dispersion were prepared by using different water soluble and insoluble carrier at different ratio. Dispersions were made by solvent evaporation technique and undergo drug content test, compatibility by FT-IR, DSC thermal study and in vitro drug release study. FT-IR and DSC thermographs showed the compatibility of the drug and carrier in the incorporated ratio. All the preparations were found to improve the dissolution behavior of Simvastatin significantly compare to the binary physical mixtures and the pure drug. The suitability of solid dispersion and surface solid dispersion technique was evaluated. Also the efficacy of the carriers to improve the dissolution behavior was compared. Tablets were formulated by incorporating dispersions and were subjected to various physical tests including thickness, diameter, hardness, average weight and disintegration time. Their release pattern was compared with compressed matrix of drug and two brand products available in Bangladesh market. Their drug release pattern was further characterized with mean dissolution time (MDT), fractional dissolution time (T50% and T80%) and percent dissolution efficiency. Tablets made of dispersion with HPMC, sodium starch glycolate and croscarmellose sodium were found to have better release rate and extent than the drug and the brand products.

  A rapid and sensitive UV-Visible spectroscopic method was developed for the estimation of cefuroxime in pure and its Pharmaceutical formulations. The method was based on the measurement of absorbance of Cefuroxime active moiety of Cefuroxime tablet at 277 nm using methanol as solvent. The absorbance was found to increase linearly with increase in concentration of Cefuroxime which was corroborated by correlation coefficient values. The standard solution of Cefuroxime obeyed Beer’s law over the concentration range of 9.20–27.60 µg/mL. The method is linear (from 9.20-27.60 µg/mL) with an R2 of 0.999, accurate (% recovery 100.56%) and precise (% RSD 0.316%). The method is specific and robust for Cefuroxime. Key words: Cefuroxime, Spectrophotometric method, validation, accuracy