RajeevKumar R. Singh

  This research paper describes simple analytical method for determination of Camylofin dihydrochloride and Paracetamol in syrup formulation by Gas chromatography method. Benzoic acid was used as internal standard. Validation was carried out in compliance with the International Conference on Harmonization guidelines. The method utilized GC (Agilent Technologies 6890N Network GC system with FID detector), and RTX-5 capillary column (Crossbond 50% diphenyl-95% dimethyl polysiloxane), 30m x 0.53mm, 1.5µm as stationary phase. Helium was used as the carrier gas.  The proposed method was validated for linearity, LOD, LOQ, accuracy, precision, ruggedness and solution stability. It can be conveniently adopted for routine quality control analysis. Key Words:Validation, Gas chromatography, Pharmaceutical preparations, Camylofin dihydrochloride, Paracetamol.

  An HPTLC method for simultaneous determination of Camylofin Dihydrochloride and Diclofenac Potassium in a pharmaceutical formulation has been developed and validated. The analyte were separated on silica gel 60F254 HPTLC plates with Benzene: Methanol: Ammonia in the ratio of 8.0:2.0:0.2, as mobile phase, after chamber saturation for 15 min. The development distance was 9 cm. The plate was then dried in air and scanned and quantified at the wavelength at 220 nm. The limits of detection were 25 μg mL–1 and 30 μg mL–1 for Camylofin Dihydrochloride and Diclofenac Potassium respectively. The limits of quantification were 50 μg mL–1 and 60 μg mL–1 for Camylofin Dihydrochloride and Diclofenac Potassium respectively. The method enables accurate, precise, and rapid simultaneous analysis of Camylofin Dihydrochloride and Diclofenac Potassium. It can be conveniently adopted for routine quality control analysis. Key words: HPTLC, Camylofin Dihydrochloride, Diclofenac Potassium.