Raja Sundararajan

Indian medicinal plants are gaining popularity in treating several diseases. Due to the plants availability and less side effects people are showing more interest in Indian medicinal plants than other source of medications. The current review is a latest and wide-ranging analysis of ethnomedical information, pharmacological uses and phytoconstituents of Bougainvillea glabra. Traditionally, the plant is conveyed for the management of helminthiasis, diabetes and respiratory tract illnesses such as cough, cold & bronchitis. It has been proved several pharmacological activities like analgesic, antipyretic, anti-inflammatory, antibacterial, antidiabetic, antiulcer, antidiarrhoea and antilipidemic. Major phytoconstituents like terpenoid, carbohydrate, fatty acids and flavonoids have been reported in this plant. This helps in supporting the plant for future studies and uses on different disorders faced due to various reasons. Further investigation and research is still required for the plant to explore various medicinal properties.

Michelia champaca, a healthful plant and it's normally utilized in people medication to treat varied diseases. The aim of the study was to evaluate the hepatoprotective & invivo antioxidant activities of Michelia champaca against carbon tetrachloride induced liver injury in rats. The methanol extract of Michelia champaca at dose of 250 and 500 mg/kg were administered orally once daily for seven days. Serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), total bilirubin (TB), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and total protein (TP) were estimated from serum. In-vivo antioxidant activity of methanol extract of Michelia champaca was evaluated by various assays including catalase (CAT), superoxide dismutase (SOD), reduced glutathione, glutathione peroxidase (GPx), glutathione reductase (GRD) and malondialdehyde (MDA) levels in liver tissues. Histopathological examination of the liver sections was carried out to support the induction of hepatotoxicity. The results of the study indicated that, methanol extract of Michelia champaca 500 mg/kg showed a major decrease in SGPT, SGOT, TB, ALP, LDH levels that were all elevated within the carbon tetra chloride treated group. The Michelia champaca extract showed considerably redoubled the degree of CAT, SOD, GSH, GPx, GRD and reduce the degree of MDA. Michelia champaca leaves extract therapy also protective effects against histopathological alterations. From the above study it can be concluded that methanol extract of Michelia champaca had hepatoprotective & antioxidant activities against carbon tetra chloride induced hepatic damage in experimental animals.