Purnima Amin

The present study deals with application of melt granulation technology to develop sustained release formulation of aceclofenac with lipidic excipients (Compritol 888 ATO). This approach is concerned with the use of minimum number of excipients to reduce the tablet weight and increase the compatibility of the drug. The continuous melt granulation/extrusion was done by optimizing the formulation as well as processing parameter such as drug loading, operating temperature, screw speed and feed rate during the process. The FTIR study revealed that there is no chemical interaction exists in between the drug and lipidic excipients while DSC and XRD studies exhibited crystalline state of the drug after melt granulation. The scanning electron microscopic examination of melt extrudates revealed the agglomerated particles with porous network and rough surface. The developed tablet (80% drug loading) has weight of  250 mg (mini tablet) containing 200mg of aceclofenac and it showed sustained release profile upto 24h.

The aim of this study was to investigate the performance and release behavior of drug from hydroxypropyl methylcellulose (HPMC) matrix tablets prepared using HPMC from three different manufacturers. Three various brands of HPMC used were Methocel, Novocoat, and Zhongbao. A protocol was followed to evaluate these three HPMC samples their physico-mechanical properties such as appearance, particle size distribution, bulk density, tapped density, angle of repose, compressibility index (CI), Hausner’s ratio, swelling and morphology. Formulations were prepared using Carbamazepine (CAR) as a drug molecule, by varying drug loading and polymer concentration to evaluate the physical and comparative performance characteristics. Various drug release kinetic models were evaluated for the best fit of the formulations in order to understand the underlying release mechanisms from the formulations. The best performance with respect to release kinetics was exhibited by Methocel,while Novocoat and Zhongbao were found to have similar performance.