Pankaj Sharma

The objective of this study was to produce the rhizome of Curcuma caesia's ultraviolet-visible (UV-VIS) and Fourier transform infrared (FTIR) spectrum profiles. For the proximate analysis, the extracts were examined in both visible and ultraviolet light. The C. caesia crude extracts. Using a Perkin Elmer spectrophotometer, the rhizome was scanned at wavelengths between 200 and 800 nm, revealing the characteristic peaks. A Perkin Elmer spectrophotometer system was used for the FTIR method, which was used to identify the characteristic peak values and their functional groups. The C. caesia UV-VIS profile. The rhizome methanolic extract had absorption values of 0.617, 1.235, and 0.557, respectively, at peaks at 256.00 nm, 288.00 nm, and 330.00 nm. The FTIR range was utilized to distinguish the useful gathering of the bioactive parts in light of various pinnacle values in the locale of infrared radiation. The current study's findings confirm the presence of the pyrocatachol derivative.

Both Qualitative and Quantitative analysis plays a significant role in promising the safety and therapeutic efficacy of drugs in variety dosage forms. A bioanalytical method is a set of procedures involved in the collection, processing, storage, and analysis of a biological matrix for a chemical compound. Bioanalytical studies are employed to obtain a quantitative measure of the drug or its metabolites for the study of pharmacokinetics, toxicokinetic, bioequivalence and exposure-response like pharmacokinetic/ pharmacodynamic studies. Leukotriene receptor antagonists are widely used for the treatment and management of bronchial asthma and allergic rhinitis in different dosage forms. Drugs of this class are Zafirlukast, Montelukast and Pranlukast which are being potent drugs and are more than 99% bound to plasma proteins presenting special challenges in the development and validation of analytical methods from a variety of matrices. The main objective of this review is discussion on various analytical methods used, different solvents used as mobile phase and their retention times to understand final optimized chromatographic method which could be useful for the assessment of Pharmacokinetic parameters. Among different analytical methods, HPLC, LC-MS, UV-Visible spectroscopy and spectroflourimetric techniques are the most widely preferred techniques applied by the researchers worldwide. This review article gives information about various types of extraction procedures of the drug in plasma matrices to create an optimized method for method development and to offer practical approaches for determining validation parameters like specificity, selectivity, recovery, lower limit of quantitation (LOQ), limit of detection (LOD), linearity, range, accuracy, precision, stability, ruggedness and robustness of High performance liquid chromatographic methods (HPLC)  to support pharmacokinetic studies. Accurate and sensitive analytical methods for quantitation of drugs and their metabolites are very important for the successful conduct of preclinical and clinical pharmacology studies..

Plants are very useful to mankind. Many of them are used exclusively for medicinal purposes. According to the World Health Organization (WHO), “a medicinal plant is a plant which, in one or more of its organs, contains substances that can be used for therapeutic purposes, or which are precursors for chemo-pharmaceutical semi-synthesis.” Such plants are in great demand by pharmaceutical companies for their active ingredients. The present study deals with the in-house formulation of herbal antidiabetic tablet Glucomap. Various evaluation parameters of tablets were evaluated and were compared with standard drug glucomap.

A new class of heterocyclic compounds 1,3,4-thiadiazolo[3,2-a]-s-triazine have been synthesized as schiff’s base of 1,3,4- thiadiazole mix with ammonium acetate and various aromatic aldehyde treated in MW irradiation at 480 W. Reaction is based on microwave mediate multi-component reaction (MCRs). The structures of these compounds have been elucidated by spectral (IR, NMR & Mass) analysis. The title compounds were then evaluated for their in-vitro microbial activity against 2 gram –Ve bacteria (E.coli, K. pneumoniae), 2 gram +Ve bacteria (S.aerues, B.subtilis) and 1 fungal specie (A.niger). The some newly synthesized compounds have shown promising antimicrobial activity.

To synthesize and characterize novel thiazolidinone derivatives and screen them for anti tubercular activity. A series of ten 2-(substituted phenyl)-3-[{4-(1-naphthyl)-1, 3-thiazol-2-yl} amino]-5-methyl-1, 3-thiazolidin-4-ones (TM1-TM10) were synthesized from 1-acetyl naphthalene. The synthesized compound, characterized on the basis of satisfactory analytical and spectral (IR, H1NMR, Mass and elemental) data. Studies were carried out for the synthesized compounds which were also evaluated for anti-tubercular activity by using Lowenstein-Jensen (LJ) acid medium and screening by Cup plate method. Rifampicin (Lupin) is used as standard antitubercular agents. The synthesized compounds showed good anti tubercular activity, compared to standard drugs. Two of the compounds TM1 (Ar = 4-nitrophenyl) and TM6 (Ar = 3-fluorophenyl) exhibited significant anti-tubercular activity, as compared to standard drug Rifampicin. We report the successful synthesis of novel thiazolidinones, as well as their spectral characterization, and anti tubercular activity which, for some, is superior to currently used anti-tubercular agents.