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As X-ray applications continue to evolve across medical disciplines, meticulous implementation of Quality Assurance (QA) protocols becomes paramount. It is the cornerstones in X-ray applications, ensuring accuracy, safety and effectiveness of diagnostic procedures. To get optimum use of medical equipment, specific performance tests must take place. The aim of this work is was to evaluate the performance of GE conventional X-ray System installed in 2007 at Radiological Science Department of King Saud University. Non-invasive auto meter used to evaluate the performance of such X-ray imaging system. The study investigates various Quality Control (QC) parameters, including milliampere-seconds (mAs) linearity, tube voltage accuracy, and exposure time reproducibility, to ensure compliance with established standards. All QC tests have done according to the intentional standard reports (AAPM No. 74) and National recommendations of King Abdullah City for Atomic & Renewable Energy. The obtained results indicate that the X-ray unit demonstrates acceptable mAs linearity, tube voltage accuracy, reproducibility and exposure time reproducibility tests and thus ensuring consistent X-ray output. All the obtained results meet the international standards. In general, the Department of Radiological Sciences adheres to strict quality control and quality assurance protocols for the department's equipment. To maintain consistency in radiation output, ensure user safety, and improve image quality in radiography. Through continuous monitoring and evaluation of equipment performance, while minimizing unnecessary radiation exposure to users.

The aim of the research study was the development and validation of a simple, rapid, accurate and precise reversed-phase high performance liquid chromatography (RP-HPLC) stability-indicating method for the determination of aceclofenac in bulk and pharmaceutical dosage forms. The RP-HPLC studies was performed on the instrument Jasco HPLC system with Jasco UV 2010 photo diode array detector, ODS C18 RP-column (Intersile 250 mm × 4.6 mm; i.d. 10 μm), Rheodyne injection syringe with 20µL loop volume and windows based chrompass software was used for separation. The isocratic elution was performed using the mobile phase ratio of methanol: water (65:35 v/v) and UV detection wavelength at 263 nm. The overall run time of the analysis was 20 minutes and the flow rate was 1.0 mL/min. The RP-HPLC method developed for analysis of aceclofenac was validated as per the ICH guidelines with respect to specificity, selectivity, linearity, accuracy, precision and robustness. The linearity for developed method was observed in the concentration range of 5-50 μg/mL with the correlation coefficient (r2) of 0.9992. The percentage accuracy of aceclofenac ranged from 99.40 to 100.79%. The relative standard deviation for inter-day precision was lower than 2.0%. The assay of aceclofenac was determined in tablet dosage form was found to be within limits. Aceclofenac was subjected to stress conditions such as neutral, acidic, alkaline, oxidation, and photolysis degradations as per ICH guidelines. The results of degradation studies revealed that the drug degraded a maximum (32.68%) in acidic conditions followed by alkaline conditions (15.05%). The drug was found to be resistant towards neutral, acidic and photolytic degradation conditions.

Prostate specific antigens occurs in serum in different molecular isoforms, and serum levels of these isoforms have been introduced as adjuncts for prostate disorder screening to reduce misdiagnosis. Little data exist on the use of these tests for screening patients with BPH . In the current study, serum level of total, free and complex  prostate specific antigen (tPSA,fPSAand cPSA) isoforms and serum sarcosine were evaluated in 200 BPH patients and 200 matched controls. tPSA level  was 15.13±1.15 ng/ml in BPH patients and 2.75±0.22 ng/ml in controls. fPSA was 2.81±0.16 ng/ml in BPH patients and 0.72±0.03 ng/ml in controls. cPSA was 12.31±1.05 ng/ml in BPH patients and 0.72±0.03 ng/ml in controls. Serum sarcosine was 118.70±1.80 nmol/dl in BPH patients and 64.94±0.81 nmol/dl in controls. The differences between patients and controls in all the analytes are significant (

Green synthesis of nanoparticles is eye catching area of nanoscience and nanotechnology. It involve development of clean, biocompatible, non-toxic and eco-friendly methods for nanoparticles synthesis as compared to conventional method like physical and chemical which are often toxic. In the  present scenario variety of nanoparticles with well-defined chemical compositions, sizes and morphology have been synthesized using different microorganisms and their applications in various cutting-edge technological areas have been explored. This review highlights the recent developments of the biosynthesis mechanisms of different types of nanoparticles using bacteria. Nanoparticles have been used in diagnosis, treatment, drug delivery, medical device coating, wound dressings, medical textiles, contraceptive devices, anti-fungal, anti-inflammatory etc. Future prospects for synthesis of nanoparticles using bacteria have also been discussed.