P.Tripura Sundari

Oral analgesics are commonly prescribed  for the treatment of acute and chronic pain, but these  agents often produce adverse systemic effects, which some times are severe ,so topical administration of analgesics is an alternative method. The  aim of  present work is to develop semi solid preparations of natural analgesics like camphor. Three different strengths were prepared which are 25mg,50mg,100mg in two different bases that are hydrophilic and hydrophobic. All the prepared  formulations  were evaluated  for PH, spreadability, diffusion studies. The selected formulations were evaluated for in-vivo studies in comparison with marketed preparations .The  finalized preparation was kept for stability studies according to ICH guidelines. Keywords: Pain, Camphor, Ointment.

Nanoparticles are submicron nano sized particles having the size range of about 1-100nm range. Because of their sub-microscopic size, they have unique material characteristics, and manufactured nanoparticles may find practical applications in a variety of areas, including medicine, engineering, catalysis, and environmental remediation. Escitalopram (ETP), an SSRI (selective serotonin reuptake inhibitor), and s-enantiomer of citalopram is exclusively used as an antidepressant. The drug shows extensive hepatic metabolism, reduced drug efficacy and potential side effects, which reduces its therapeutic index. So, the present study is focused on increasing the solubility and thus the bioavailability. The nanoparticles were prepared by using hot homogenization method by using Cutina as lipid, soya lecithin as lipophilic surfactant and PEG as hydrophilic surfactant. The prepared solid lipid Nanoparticles were evaluated for Drug content, entrapment efficiency and dissolution studies and stability studies and found that the Drug content ( 90.7%), Entrapment efficiency (  86.1 %) and Drug release of  ( 82.4%), Particle size( 796nm) and Zeta potential ( -29.4mV)