P. Kanchana

Schleicheraoleosa is (Lour.) Oken belonging to the family Sapindaceae. An ethanolic extract of Schleicheraoleosa bark was investigated for its Anti-nociceptic and anti-inflammatory activities in rats and mice. Anti-nociceptic  activity was evaluated  by using the tail immersion, tail flick and hot plate latency assay while the anti-inflammatory test were carried out using the carrageenan induced paw oedema model in rats. Pentazocin was used for analgesic activity and Indomethacin was used for anti-inflammatory activities as standard drugs. The in tail immersion, tail flick and the hot plate latency times were increased with the increase in  doses of 200, 400 & 600 mg/kg significantly. . Similarly, for the carrageenan induced paw oedema model the result show that the extracts at the doses of 200, 400 & 600 mg/kg significantly (P < 0.001) inhibited the paw oedema in a dose dependent manner. The present study proved that the ethanolic extract of S. oleosa has analgesic and anti-inflammatory activities property.