P. Durga

The burden of Chronic Kidney Disease (CKD) is increasing in alarming proportion all over the world.  According to World Health organization (WHO), CKD is 12th leading cause of death and 17th cause of disability. In India, an estimated 100-120 per million population reach Chronic kidney disease stage-V. In India due to lack of financial resources, lack of trained manpower & infrastructure leads to severe strain on existing health policies in the light of the increasing burden of  Chronic kidney disease. Maintenance dialysis is a well-recognized modality of treating patients having end stage renal disease. Good quality of life and survival on maintenance dialysis depends on various factors but unfortunately in our country, the quality of dialysis delivered to patients can vary from center to center that may affect  the health  of hemodialysis patients. This study was undertaken to analyze the post hemodialysis effects in patients with ESRD.A Prospective observational study was conducted on total of 150 out-patients undergoing maintenance hemodialysis, in order to find out the post hemodialysis effects in chronic renal failure patients and patient information was collected accordingly. In this study most of the patients undergoing hemodialysis experienced hepatitis, arthropathy and disequilibrium effects after repeated hemodialysis process. We observed that people undergoing hemodialysis experiences severe side effects which can be minimized by creating awareness so that the life expectancy of the hemodialysis patients can be increased.

Fucidin, a topical antibacterial agent indicated in the treatment of bacterial infections. It works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. The aim of the present study was to prepare topical gel by using gel forming polymers along with chitosan and to study the effect of the concentration of polymers, effect of alone Fucidin, combined effect of Aloe Vera with vitamin C on different gel parameters and wound healing activity. The gel formulations were prepared by soaking method using Carbopol 934p as gelling agent/gel base. IR spectroscopy studies suggested that the formulations prepared is a physical mixture and the drug is compatible with other excipients. The prepared gel formulations were evaluated for drug content, pH and rheological parameters like viscosity, spreadability and extrudability. The percentage release of Fucidin from plain gel was slow as compared to other drug loaded gel formulations. The formulation (F8) showed maximum percentage release (99.56%). All the gel formulations showed more than 80% reduction in wound contraction. The gel formulation containing Fucidin along with 1% chitosan and 1% sodium alginate showed 99.4% reduction in wound area after 12 days.