Nandkishor Chandan

The thiol acetic acid and acetic anhydride both has been used for nucleophilic acyl substitution of phenols in two different methods. Both methods are simple and inexpensive by using aqueous NaOH base with acetic anhydride and no catalyst required for thiol acetic acid reaction. This can be a key method for identification of phenolic functional groups.

Ring acylations of aromatic substances are very difficult to achieve to a great extent. Nencki reaction has attempted on mono to poly hydroxy and substituted phenols have good results. Reactions are using solely acetic acid, acetic anhydride and adipic acid or mixture of acid and anhydride resulting complete consumption of phenols. The use Lewis acid freshly fused ZnCl2 is best suitable catalyst compare to others. The essential data on phenols acylation has been studied and described as below. 

Through this review we would like to introduce clean and efficient method of most conventional Friedel-Craft acylation of phenols using Ionic liquid. This method has best results of acylated phenols in terms of quality and yields are concerned. The Friedel-Craft acylation is an everyday applicable industrial synthesis. Phenols are dihydric, trihydric as well as monohydric hydrocarbons used to undergo acylation. Acetyl chloride is best suitable reagent for aromatic C-acylation. Ionic liquid [EMIM][AlCl4] has best solvation and catalytic effect in the reaction. Key Word: Friedel-Craft Acylation, Phenols, Ionic liquid [EMIM][AlCl4], Acetyl Chloride  

The synthesis of Nitrogen base heterocycles particularly highly substituted piperidine are very important structural motif which is present in numerous natural alkaloids including piperine, nicotine, coniine etc and non-natural substances too. The piperidine is extracted from black pepper1,2, Psilocaulon absimile (Aizoaceae)3 and Petrosimonia monandra4.   The functionalized piperidine derivatives are ubiquitous building block in synthesis of pharmaceuticals and fine chemicals, consequently it attract interest, both for their synthetic challenges,5 and also their value in synthetic chemistry6 and diverse biological activity.7 The present work includes the synthesis of highly functionalized piperidine derivatives using the Oximation of Michael adducts (scheme 3). The target product was oxime for further reaction but instead of the required oxime as product the side product with six member heterocylic product was formed as major product. The yield of side product was depends on time and thermodynamic conditions. Owing to the new results which were confirmed by singe crystal X-rays and NMR data, we have developed this methodology which gives easy access to the synthesis of highly substituted piperidine (Scheme 3). This strategy is very simple and efficient to have 2,3,4,6 substituted nitrogen containing heterocycle as Piperidine.

The synthesis of Nitrogen base heterocycles particularly highly substituted pyrrolidines are very important skeleton of many biologically active molecules1 including natural and non-natural substances. The synthesis of functionalized pyrrolidines persists to attract interest, both for their synthetic challenges,2 and also their value in synthetic chemistry3 and their diverse biological activity.4 The present work includes the synthesis of highly substituted pyrrolidines through double Michael addition reaction of acetylene carboxylate with substituted malonate and amine in one pot results into the cyclisation. This methodology gives substitution pattern on 2, 2, 3,3,5-position of the pyrrolidines Scheme 1 and 3. This strategy is very simple and efficient to have highly substituted nitrogen containing heterocycle as pyrrolidines.