M.P.Ratnaparkhi

Herps zoster is a viral infection and a common disorder of the eyes. It is caused by herpes simplex virus: herpes virus type 1(HSV-1) & herpes virus type 2 (HSV-2). Topical acyclovir is currently the only and safe pharmacologic treatment of severe viral infection of the eyes. Nanoparticulate formulations have advantage of improving residence time over ocular surface, reduced size increasing permeation across corneal surface for intraocular activity. The objective of this study was to prepare and evaluate Acyclovir (Acy)  nanoparticles (NPs) for the treatment of Herps zoster infection of the eyes. So, the present study was designed with the primary aim to prepare nanoparticles by nanoprecipitation method using cationic polymer Eudragit E100 and secondly to study the effect of variables on the behaviour of nanoparticles. Preliminary study showed the compatibility of the drug with the formulation. Optimization was done using full factorial design with independent variables such as Drug to polymer ratio, Organic: aqueous phase ratio and effect of type and concentration of stabilizer. The dependent variables were determined such as particle size, drug entrapment, % drug release selected as the levels. F21 formulation was selected as the final optimized formulation.

The objective of the present study was to formulate a solid self micro emulsifying drug delivery system (SMEDDS) for oral administration to improve the solubility and bioavailability of Nimorazole. Solubility was determined in various oils, surfactants and cosurfactants. Of  all the oils accessed for drug solubility, Capmul PG 8 NF showed higher solubility for drug and was better microemulsified using combination of Labrasol and Labrafac CC surfactant. The optimal formulation consists of 30% Capmul PG 8 NF, 50% Labrafac CC,20% Labrasol , was adsorbed on carriers Aerosil200, Microcrystalline cellulose (MCC) and Kaolin .The SMEDDS and solid SMEDDS were characterized for Percent transmittance (%T). Those formulations which showed higher value for %T were evaluated for droplet size, polydispersity index, ζ potential, refractive index and cloud point measurement. Effect of drug loading on droplet size, increasing dilution in different media, thermodynamic stability and in vitro dissolution was performed to observe the performance of the selected formulation. The solid SMEDDS are characterized by globule size analysis, and drug release studies of formulations are compared with plain drug. Adsorption on kaolin produced SMEDDS with the desired globule size and drug release. There was an increase in both the solubility and dissolution rate of drug in S-SMEDDS-K3 as compared to dissolution rate of pure Nimorazole.