Lotika Chawla

Conventional dosage forms like tablets and capsules are now a days facing the problems like dysphagia, resulting in the high incidence of non compliance and making the therapy ineffective. To obviate the problems associated with conventional dosage forms, mouth dissolving tablets have been developed having good hardness, dose uniformity, easy administration and serves as the first choice of dosage form for paediatrics, geriatrics and travelling patients. The MDTs were developed with an aim of having sufficient hardness, integrity and faster disintegration without water. Various approaches for the formulation of MDTs include Direct compression, Wet granulation, Freeze drying, Spray drying, Moulding, Cotton candy process and Sublimation. Novel technologies like Zydis Orasolv, Durasolv, Flash dose technology, Wowtab etc are available as patented technologies, most commonly used in preparation of MDTs. Drugs belonging to antibiotics, antiviral etc are now formulated as MDTs to minimize the draw backs of conventional dosage forms. Examples of Marketed MDTs are Cefadur DT, Zofran ODT, Acivir DT etc. Due to wide significance of MDT, this drug delivery system may lead to better patient compliance and ultimate clinical output.