Lana Yousif Mutalib

Efforts have been spend for discovering drugs from medicinal plants. Hibiscus sabdariffa plant a well known plant with many traditional uses for treating different aliments have been selected for canvassing pharmacological activities expressed by the different polarity extracts. Results showed significant antidiabetic activity at different concentrations of glucose solution (5, 10 and 20 mM) (p value < 0.001). Significant moderate anti-inflammatory activity comprising in membrane stabilizing activity were expressed by ethanolic extract ranging (29.573±0.709 - 55.040 ±1.659 %) (p value < 0.001) while mild activity were expressed by petroleum ether extract ranging (10.273±0.413 - 22.347± 1.049 %). Approximately similar thrombolytic activity was exhibited by both extracts ranging (56.663±1.3139-21.533±0.656) consider as significant activity in comparison to the control negative (p value < 0.0001). Results conclude canvass the pharmacological activities expressed by different polarity extracts which were showed significant activity in some aspects which may open new venue for production of new drugs derived from nature with less side effects.

Phytochemical are compounds derived from natural source play important role in mankind health system with various physiological activities such as antioxidant and thrombolytic activity. Borago officinalis leaves have been assessed for quantity of antioxidant compounds comprise in estimation of total phenolic, total flavonoid and total tannin contents, and thrombolytic activity of hydrolacholic leaves extract at different concentration ranges. The hydroalcholic extract of leaves showed low phenolic contents about (26.45 ± 0.126 mcg GAE\g DW) with approximately similar quantity of total flavonoid and total tannin contents about (212 ± 0.278 mcg QE\g DW) and (216 ± 0.521 mcg GAE\g DW), respectively. Leaf extract exhibited a dose dependent manner thrombolytic activity ranges between (8.346± 0.669 - 44.6697±1.1076) considered significant in comparison with control negative distilled water (p value < 0.0001) and moderate activity in comparison with control positive streptokinase. Borago officinalis leaf was a good source for antioxidant compounds and open a venue for production of thrombolytic agents from the leaf with less side effects in comparison to the conventional drugs.