Krishnananda Kamath K

The present work is aimed at Design and development of medicated lollipop containing Albendazole. One of the major health problems faced by hundreds of millions of school-age children is infection by helminths, more commonly known as worms. Albendazole is used as abroad-spectrum anthelmintic. The conventional dosage forms like tablets, capsules, syrups etc are inconvenient for paediatric, geriatric, bedridden patients because of difficult to swallow tablets and capsules or unpleasant taste of drug. As a result, the demand for developing new technologies has been increasing day by day. Lollipops are defined as the flavoured medicated dosage forms intended to be sucked and held in the mouth or pharynx containing one or more medicaments usually in the sweetened base.  Medicated lollipop is designed to improve patient compliance and increase oral retention time. The lollipops were prepared by heating and congealing method using hydroxypropylmethylcelluloseK4M as polymer. Drug-excipient compatibility study was carried out using FTIR. All the formulations were subjected to various physicochemical evaluations like weight variation, hardness, drug content, friability etc. The in-vitro dissolution study of F3 was carried out by two method a) Paddle method b) flow through cell method .The in-vitro permeation  study of F3 was found to be 72.2% at 30 min. Stability study was carried out as per ICH-Guidelines (Q1A) at 25±2oC/60±5% RH and 40±2oC/75±5% RH . From the present study it can be concluded that addition of hydrophilic polymers yield good result to prolong oral retention time of lollipop.

  Pharmaceutical supply chain has always been a point of great interest in academic research as well as in industrial practice. However this popular buzzword still remains an ill-defined and poorly understood concept and this will provide a better understanding of the different levels of pharmaceutical supply chain issues and the terms regarding supply chain for pharmaceuticals. Though the pharmaceutical industry has grown by leaps and bounds the risk affecting it has also increased proportionately. Furthermore this addresses the issues of risk mitigation in pharmaceutical supply chain by providing quantified empirical results. Based on the available literature four major risks affecting the pharmaceutical supply chain were identified as regulatory risk, inventory risk, counterfeit risk and financial risk. Ranking and management strategies of these are based on Analytical Hierarchy Process model. Also solutions to these risks are provided based on the results of the survey questionnaires and literature study which would be best suited for the industry to flourish and survive in today’s competitive global marketplace.