Konda Ravi Kumar

Phenothiazine is an organic compound and it is related to the thiazine class of heterocyclic compounds. A novel series of Phenothiazine derivatives were prepared by the reaction of Para amino benzoic acid with 3 different substituted anilines. All the compounds were characterized by melting point, UV, TLC, IR and C,H,N elemental analysis. The synthesis of 3 derivative compounds were prepared, those are 3 derivatives of substituted phenothiazine were prepared in scheme 1 from p-chloro benzoic acid aniline derivatives. All the compounds were structurally elucidated with physical and analytical methods. All the compounds evaluated with invitro anti inflammatory activity by protein denaturation method. The synthesized derivatives were screened for invitro anti-inflammatory activity. 5C Compound showed significant effect at 200-1000 µg/ml.

Synthesis of phenyl (5-substituted phenyl-1,3,4-thiadiazol-2-yl) methanediamine (TDZ-A to TDZ-C), reaction between aryl aldehydes and Thiosemicarbazide yielded thiosemicarbazone. Thiosemicarbazone in the presence of citric acid and sodium acetate gives 2-amino-5-aryl -1,3,4-thiadiazole, which is treated with aniline in the presence of formaldehyde to obtained targeted compounds phenyl(5-substituted phenyl-1,3,4-thiadiazol-2-yl)methanediamine. The synthesized Thiadiazoles have been characterized on the basis of analytical spectral data. The resulted compounds were screened for their antibacterial, antifungal and antioxidant activities.

The safety of human exposure to an ever- increasing number and diversity of electromagnetic field EMF sources both at work and at home has become a public health issue. Deficient sperm production may be affected by factors such as radiation and other environmental toxins. Raised body temperature for any reason, and raising scrotal temperature by sitting in sofa or in hot water for a long period of time, can reduce sperm production. Healthy young men who watched more than 20 hours of TV each week had a 44 per cent lower sperm count than those who watched almost no TV. Radiations and excessive heat to the genitalia have damaging effect on the testicles. Hence individuals having direct contact with or exposure to such chemicals have high chances of having primary or secondary infertility. . Intense exercise didn't raise sperm count if accompanied by lots of hours in front of the TV.