K.Ramalingam

The present study was aimed to investigate the antibacterial and antifungal activity of aqueous, methanol, ethanol, petroleum ether and acetone extract of canthium coromandelicum using disc diffusion method. The antibacterial activity was detected against Gram-positive and Gram-negative bacteria, Bacillus subtilis, Bacillus ceresu, Staphylococus aureus, Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa. Different solvent extracts of canthium coromandelicum was taken in 100,150,200 and 250 μl/ml. The zones of inhibitions obtained were recorded and analyzed against standard controls, Streptomycin and Amphotericin. The methanolic extract of canthium coromandelicum was showed highest antibacterial activity than ethanolic and aqueous extracts. The higher concentration of methanolic leaves extract of canthium coromandelicum plant, maximum antibacterial activity was observed against to Gram-negative bacteria than Gram-positive bacteria and antifungal activity against to Candida lbicans,  Aspergillus niger. The results indicate that canthium coromandelicum leaves also has potent antibacterial  and antifungal activity.