K.Krishnakumar

Pyrazolines, the eminent five-membered nitrogen-containing heterocyclic compounds, have received significant interest in the fields of therapeutic and agricultural chemistry because of their broad spectrum of biological activities. The Pyrazoline ring is relatively stable and has inspired chemists to carry out various research activities. Pyrazolines, a class of electron-rich nitrogen heterocyclic compounds, possess a broad range of pharmacological functions such as anticancer, antitubercular, antimalarial, antibacterial, antifungal, anti-inflammatory, analgesic, anticonvulsant, and antioxidant activities. This review provides an outline on the recent grade of pyrazoline derivatives in terms of synthesis and various applications to realize their full potential as drugs.

Complementary and alternative medicine (CAM) refers to a wide range of clinical therapies outside of conventional medicine the term “complementary “ refers to  the therapy that are used in conjunction with conventional medicine where as alternative medicine includes therapy that are used in place of conventional medicine. The term “integrative medicine that has been advocated by some CAM providers More than one-third of patients with diabetes in the united state use some type of complementary and alternative medicine herbs, dietary   supplements and mind body medicine are the most commonly used studies and CAM modalities to treat diabetes including proposed mechanisms a summary of evidence and adverse effect. It also offers recommendation for counseling patient regarding CAM use. The use of CAM for patients with diabetes was reported to be common in almost all parts of the world However, different definitions were used for CAM, which was one of the reasons for a wide range of prevalence of CAM use ranging from 17% to 73% CAM use prevalence in the USA ranged from 31% to 57% among diabetes patients , 63% in Bahrain 62% in Mexico 7% in UK  and 25% in Canada  China had a long tradition of use of herbal medicine for diabetes The findings of a systematic review reported that Chinese herbal medicines were reported to be more effective for diabetes compared with lifestyle modification alone  In China, traditional medicines accounts for 40% of all healthcare.