Jyotsna Meshram

Herein, a series of azetidinone derivatives incorporating dihydropyrimidinone moiety 4(a-h) were prepared. The structures of newly synthesized compounds were confirmed on the basis of elemental analysis, FTIR and 1H NMR spectroscopy. The synthesized compounds were evaluated for their anthelmintic and anti-bacterial activity and it was found that the compounds were pharmacological active and gave appreciable results.

The present work deals with the synthesis of azetidinone derivatives of quinazolinones and  the structures of the compounds obtained have been established based on spectral (IR, 1H NMR,13C NMR and Mass) data. The present study also involves in vitro anthelmintic and antibacterial activity of the synthesized derivatives a few strains (gram positive and gram negative) of bacteria. All the compounds showed against moderate to satisfactory activities.