Durgesh Nandkishor Boob

This experiment, first developed for a NSF Novel Process Workshop, is a highly visual experiment in chemical engineering processes and experimentation. In addition, it the coating process is environmentally benign because it has essentially no volatile emissions. The object of the experiment is to place a protective coating on a pellets, tablets, and metal object. The metal object is coated by first heating in a hot air stream and then dipping the object into a fluidized bed of thermoplastic powder. This experiment can be used throughout the curriculum.  For recruitment at the precollege and freshman level the fluid motion of the gas and particles can be observed through the clear plastic walls of the fluidized bed.  Using brightly colored particles gives the fluid bed the look of an executive desk amusement.  Prospective students and freshman can also feel the water like quality of the bed using a rod or ruler.  Freshmen use the fluidized bed as an example of the engineering measurements of flow rate, temperature, pressure and coating thickness.  They design an experiment to determine the desired coating thickness by varying the dipping time and temperature of the object.

In the pharmaceutical industry an impurity is considered, defined the any other organic material besides the drug substance or pharmaceutical ingredients.  The impurity may be formed during the formulation or upon aging of two APIs in medicines. The highly sophisticated instrumentation, such as mass spectra meters attached to the gas chromatography or HPLC in various matrices. GC is the most useful technique for identification of residual solvent. The advent of hyphenated technique has revolution any impurity profiling, by not only separation but structural identification of impurities as well among all techniques. The most exploited techniques for impurities profiling of drug are LC-MS-MS, LC-NMR, LC-NMR-MS, GC-MS AND LC-MS.