Devansh Mehta

Peptic ulcer disease (PUD) constitutes one of the most persistent gastroenterological disorders worldwide, with significant morbidity linked to gastric acid hypersecretion, oxidative stress, Helicobacter pylori infection, NSAID exposure, and compromised mucosal defensive integrity. Although numerous pharmacological options—including proton pump inhibitors, H? antagonists, prostaglandin analogues, and antibiotics—are available, their long-term utility remains constrained by adverse effects, recurrence, microbial resistance, and inadequate mucosal restitution. This has catalysed renewed scientific interest in botanicals with multifaceted gastroprotective actions. Trichosanthes dioica (Roxb.) leaves represent a phytochemically dense cucurbitaceous plant component historically utilized in Indian ethnomedicine for gastrointestinal, metabolic, hepatic, and inflammatory conditions. However, compared to fruits and roots, the leaves remain considerably under-investigated despite their rich flavonoid, phenolic, triterpenoid, saponin, and cucurbitacin profile. This review undertakes a rigorous pharmacognostic, phytochemical, mechanistic, and experimental examination of the gastroprotective potential of T. dioica leaves. Mechanistic emphasis is placed on antioxidant reinforcement, modulation of oxidative microenvironment, regulation of prostaglandin-mediated defence, inhibition of parietal proton pump activity, suppression of inflammatory cascades, stabilization of mast cells, modulation of nitric oxide bioavailability, and acceleration of epithelial restitution. The article aligns with the structural, stylistic, and referencing standards of the American Journal of PharmTech Research (AJPTR). The cumulative evidence demonstrates that T. dioica leaves exhibit significant gastroprotective effects, warranting their consideration as a promising phytopharmaceutical candidate for future antiulcer therapeutics.

Quantum computing the recently invented computing power helps in carrying out calculations at really high pace. This will in other way boost the power of Artificial intelligence and its advantages to research activities altogether. As quantum computing computes at the power of qubits, so the artificial intelligence which is the intelligence of human mind would be enhanced. Hence this letter has been written in order to emphasize the development of super human power in terms of computers, which means the research would be done at super human intelligence. Keywords: Artificial Intelligence, Quantum computing, Super Human research development, Molecular Research

Medicinal Plants form the basis of traditional medicinal system. The medicinal plants usage is higher in developing countries with respect to the developed nations. In past the usage of medicinal plants use of medicinal plants and traditional medicines derived from medicinal plants has increased at great pace. The reported sales of medicinal plants or herbal medicines have crossed $ 60, 000 million dollars in year after 2000. Luffa accutangula is herbal plant, whose fruit is commonly used as vegetable as well as traditional medicines derived from medicinal plants were reported to be around 40 to 50 percent of population using it in Germany, around 43 percent usage in America, and around 48 percent in Australia and 49 percent in France. However in recent few decades (i.e. three decades) in Asian countries the sales have risen sharply. The plant is highly rich in medicinal values, and many pharmacological activities have been reported in the plant. Looking at the richness of Gourd (Luffa accutangula) the present review has been written in order to provide an up-to-date report on this imperative species of medicinal plant. Keywords: Medicinal plants, Herbal remedies, Pharmacology of medicinal plants, Luffa accutangula  

Ulcer is lesion on skin or internal linings of organs or Gastro-intestinal tract, which leads to degradation of cells in the area of occurrence which may be followed by bleeding or cancer at later stages. Peptic Ulcer Disease known as Ulcus pepticum have mucosal erosions equal to or greater than 0.5 cm of an area of the gastrointestinal tract that is usually acidic and thus extremely painful. The present study was to evaluate Anti-ulcer activity in Trichosanthes dioica (Roxb.) via experimental ulcer models in animals through Histopathology study of Rat’s stomach. The leaves of Trichosanthes dioica (Roxb.) were collected from farms in and around Hastinapur district. Around two kilograms of the leaves of plant shrub were collected and were kept in shade for the purpose of drying the leaves completely. Sprague-Dawley rats (150 – 200 g) were procured from the animal house of Subharti University (n=90). The three animal models were used for the present study, mainly, Pylorus ligation, Ethanol Induced and Indomethacin (NSAID’s) ulcer models. Five groups of Animals were made, with n=6 for each group. The histopathology study of rat’s stomach was carried out for each ulcer model, and during the examination of rat’s stomach, it was clearly shown, that Trichosanthes dioica has potent Anti-ulcer activity. The Research thus primarily focuses using the plant for further study and to bring an effective and efficient ulcer healing drug in the market.

Ulcer is tissue erosion, either on skin or inside the body, for e.g. lining of gastrointestinal tract. The diverse causes for ulcer development range from, Genetic factors to Physiological/ Environmental factors. Helicobacter pylori recently found to be responsible for majority of peptic ulcer cases. Peptic ulcer diseases are extremely common in developing and developed countries with annual incidence of 1 to 3 per 1000th of the population. PUD is an important cause of morbidity and health care costs; estimates of expenditures related to work loss, hospitalization, and outpatient care are $5.65 billion per year in US. It affects 1 in 10 men & 1 in 15 women in Europe. Due to side effects from conventional drug therapy and non-specificity of therapeutic choices, there is inclination towards Traditional medicines with low cost and low adverse effect incidences. Many photochemical substances have been found to be effective against pathogenic factors responsible for ulcer formation and its severity. Alkaloids, Flavonoids, Terpenoids, & Tannins have been researched to possess potent Gastroprotective activities. Glycosidal components have been found effective against Helicobacter pylori gram negative strains. Trichosanthes dioica (Roxb.) found in flora and fauna of Uttar Pradesh have high concentrations of terpenoids, flavonoids, cucurbitacins, which have been researched for having anti-inflammatory and wound healing activities. The present study clearly shows the effectiveness of Trichosanthes dioica (Roxb.) in having Gastroprotective activity. This gives clear indication that Trichosanthes dioica shall be researched upon to bring effective drug in market against ulcer diseases.