David Punitha
Publications by David Punitha
2 publications found • Active 2012-2012
2012
2 publicationsLC-ESI-MS Determination of Bioactive Components from the aerial parts of Stephania Wightii (Arn.) Dunn (Menispermaceae) - an Endemic Medicinal plant from Western Ghats, Kerala, India.
The present investigation was carried out for phytochemical profile from aerial parts of methanolic extracts of Stephania wightii by using Liquid Chromatography-Electronic Spray Ionization-Mass spectrometry (LC-ESI-MS). The results confirmed the presence of eighteen compounds in the crude extract and the pharmacological activities of the identified compounds were listed. The presence of various bioactive compounds justifies the use of the whole plant for various ailments by traditional practitioners.
Inhibition of cancer cell growth by crude ethanolic extract of Tinospora malabarica (Miers) Ann. An endangered medicinal plant
An ethanolic extract of Tinospora malabarica (Menispermaceae) was studied for its effects on growth in two malignant cell lines including a Human Melanoma cancer cell lines (A 375) and Skin cancer cell lines (A 431) using MTT assay. In these cell lines studied, the extract decreased cell viability, inhibited cell proliferation, and induced cell death in a dose dependent manner. The ethanolic extract of T. malabarica showed good cytotoxicity and IC50 value of 49.87μg/mL and 112.54 µg/mL respectively. It could be a reliable source of potent pharmacophore for treatment of disease like cancer.