D.B.Vaghela

Triphala is an important Ayurvedic formulation containing, Haritaki (Terminalia chebula Retz),Vibhitaki (Terminalia bellarica Roxb),Amalaki (Emblica officinalis L.) as a ingredients. All the constituents are available and prepared according to the reference present in Yoga Ratnakara Madhyama Khanda. Triphala (Haritaki, Vibhitaki and Amalaki) classified as an important medicine of the Rasayana and Cakshusya group which is mainly indicated in Prameha, Sthoulya and Kustha and also it is believed to promote health, immunity and longevity. Though they are individually very potent drug and have their own specific mode of action on different disease conditions. Triphala the sense of its Rasa, Vipaka and to some extent its Prabhava is similar to its three contents but its Virya, Doshagnata and Guna are not exactly similar to the composing three drugs. This is due to Samyoga Samskara by which the clinical efficacy of particular drug changes several methods are adopted to prepare Triphala some uses equal proportions (1:1:1) some in different proportions (1:2:4). Till date there is only one scientific work has been carried out and less publication of 1:2:4 combination forms of Triphala. In the present study the Yavakuta formulation of Triphala was subjected to Pharmacognostical (microscopic), HPTLC, and pharmaceutical (evaluation of various physiochemical parameters) evaluation in order to prepare a preliminary profile of the formulation. The sample was subjected for various phytochemical parameters like water soluble extractive (55.8%w/w), alcohol soluble extractive (42.2% w/w), ash value (0.89% w/w), loss on drying (11.39% w/w), and the pH (5.0), HPTLC. The HPTLC, solvent system was Toluene:ethyl acetate (9:1), showed the presence of 5 spots at 254 nm and 2 spots at 366 nm. Thus the physiochemical and microscopic characters achieved may provide guidelines for standardization of formulation, Triphala Yavakuta combine formulation (1:2:4).

In the era of increasing demand for indigenous medicines, maintaining quality standards is the need of the hour. Standardisation of compound formulations is lagging behind because of absence of reference standards. Manjishthadi Ghanavati is an important Ayurvedic formulation containing Manjishtha (Rubia cordifolia Linn.), Haritaki (Terminalia chebula Retz.), Amalaki (Emblica officinalis Gaertn.), Bibhitaki (Terminalia bellerica Roxb.), Katuki (Picrohriza kurroa Royle. ex Benth), Vacha (Acorus calamus Linn.), Daruharidra (Barberis aristata DC) Guduchi (Tinospora cordifolia Willd.) and Nimba (Azadirechta indica A Juss.). All the constituents are available and prepared according to the reference present in Sharangadhara Samhita Madhyama Khanda Chapter 2/136. Hence the present study was undertaken to standardize the compound Ayurvedic formulation through Pharmacognostical and pharmaceutical evaluation. The sample was subjected for various phytochemical parameters like water soluble extractive (49.72%w/w), alcohol soluble extractive (41.28 % w/w), ash value (10 % w/w), loss on drying (10.85 % w/w), the pH (6.0), Hardness(4 kg/cm2) and Disintegration time (32 min.). The HPTLC, solvent system was Toluene: ethyl acetate (9:1), showed the presence of 7 spots at 254nm and 2 spots at 366nm. Thus, the physiochemical and microscopic characters achieved may provide guidelines for standardization of formulation Manjishthadi Ghanavati.

Gutika Anjana is an important Ayurvedic formulation containing Gairika (Ochre), Saindhava (Sodii chloridum), Pippali (Piper longum Linn.) and Shunthi (Zingiber officinale  Roxb.) as main ingredient. All the constituents are available and prepared according to the reference present in Sushruta Samhita Uttaratantra Vataabhishyanda Pratishedha. Till date no work has been carried out to standardize the formulation. Hence the present study was undertaken to standardize the compound Ayurvedic formulation through Pharmacognostical and pharmaceutical evaluation. The sample was subjected for various Phytochemical parameters like water soluble extractive (32.8%w/w), alcohol soluble extractive (32.3% w/w), ash value (8.4% w/w), loss on drying (14.25% w/w), the pH (6), HPTLC. The HPTLC, solvent system was Toluene:ethyl acetate (9:1), showed the presence of 11 spots at 254nm and 13 spots at 366nm. Thus the physiochemical and microscopic characters achieved may provide guidelines for standardization of formulation, Gutika Anjana.