D. Rama Brahma Reddy

The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Aceclofenac with different ratios of hydrophilic (hydroxyl propyl methyl cellulose) and hydrophobic (methyl cellulose) polymeric systems by the solvent casting technique. Formulated transdermal patches were physically evaluated with regard to thickness, weight variation, drug content, flatness, tensile strength, folding endurance, percentage of moisture content and water vapour transmission rate. All prepared formulations indicated good physical stability. In-vitro drug studies of formulations were performed by using Franz diffusion cells. The results followed the release profile of Aceclofenac followed mixed zero-order. However, the release profile of the optimized formulation F9 (99.50±0.09) indicated that the permeation of the drug from the patches was governed by a diffusion mechanism. Formulation F9 showed highest flux among all the formulations and 217±7.42 fold enhancements in drug permeation.

The present study was carried out for screening of preliminary phyto-chemical constituents and anti-microbial activity of ethanolic extract of ASCLEPIAS CURASSAVICA. The dried extract obtained by soxhlet extraction was subjected to qualitative phyto-chemical screening for the identification. The anti-microbial activity of A.curassavica flower & plant extract by agar well diffusion method. Our study reveals that B.subtilis & E.coli showed good inhibitory zone in ethanol solvent extract