Chandrakant S. Bhaskar

A series of substituted 1, 2, 4-triazole derivatives have been synthesized, using chloroform mediated phenylimino dichloromethane. It was added to a chloroform suspension of N'-(arylidene) ethanehydrazonohydrazide and the mixture was refluxed over water bath for 3 hours. The evolution of hydrogen chloride gas was noticed. The structures of synthesized compounds are confirmed on spectral analysis like IR; 1H NMR and 13C NMR data. All newly synthesized compounds were screened for their antimicrobial activity towards Gram-positive and Gram-negative bacterial strains and antifungal activity including  B. subtilis, E. coli, S. aureus, S. ablong, Candida and A. niger. Results showed that most of compounds have measurable antibacterial and antifungal activity.

A clean and efficient route was established to synthesize sulfonamido-thiocarbamides via one-pot reactions in aqueous medium without use of a catalyst and/or organic solvent. The reaction with stoichiometric molar portion could be carried out in an open atmosphere to offer sulfonamido-thocarbamides in good to excellent yields and purities. The novel and clean methodology offers the advantages including short reaction time, excellent yields, operational simplicity, less leaks and environmentally benign path. The identity of newly synthesized compounds is based on elemental and spectral data. They have been further screened for their microbiological activities.

H2O-mediated efficient, tandem synthesis of barbituryl thiocarbamides by the nucleophilic addition reaction of uramil and aryl isothiocyanates using Amberlyst-15 as a heterogeneous solid catalyst is being reported. The novel and clean methodology offers the advantages that includes short reaction time, good yields, and operational simplicity, less leaks, environmentally benign procedure apart from recyclable, reusable catalyst. Keywords; Thiocarbamides, green synthesis, Amberlyst-15.