Bhavani Boddeda

Improvement of patient’s compliance has always a challenge towards the development of oral drug delivery system. Different dosage forms are available in the market among all oral dosage form is preferred one. However, the incompliance of pediatric & geriatric patients the scientists worked towards fast dissolving solid dosage form to encounter existing drawbacks with unique palatability and rapid disintegration. The concept of fast dissolving tablet came into existence in late 1970s. Recently, fast dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery system, because they are easy to administer and lead to better patient compliance. For further improvement in existing technologies and newer technologies has been succeeded and still research is going on in improvement with its preparation methodologies all over the globe. Fast dissolution tablets have faster disintegration and dissolution rate and release within 30 seconds as they come in contact with saliva. These systems also obviate the requirement of carry water during drug administration. As fast dissolving tablets falls under desired expectation of safer, convenient and economical solid dosage forms, several techniques have been developed to improve disintegration quality in the recent past years. This article mainly focuses on patented technologies with recent advancement made so far in the field of the fast dissolving tablets.

Buccal delivery of the desired drug using mucoadhesive polymers has been the subject of interest since the early 1980s. Advantages associated with buccal drug delivery have rendered this route of administration useful for a variety of drugs. This review highlights the use of mucoadhesive polymers in buccal drug delivery the mucosa of the oral cavity presents a formidable barrier to drug penetration and one method of optimizing drug delivery is by the use of adhesive dosage forms. Mucosal adhesive materials are hydrophilic macromolecules containing numerous hydrogen-bonds –forming groups. They have been called “wet” adhesives in that they require moisture to become adhesive and this may be supplied by the saliva: the latter may also acts as the dissolution medium. Various buccal-adhesive formulations have been investigated with a view to delivering drugs locally or systematically. We focus on the new generation of mucoadhesive polymers such as thiolated polymers, followed by the recent mucoadhesive formulations for buccal drug delivery.